A federally approved heart medication shows significant effectiveness in interfering with SARS-CoV-2 entry into the human cell host, according to a new study by a research team from Texas A&M University and The University of Texas Medical Branch (UTMB).
The medication bepridil, which goes by the trade name Vascor, is currently approved by the U.S. Food and Drug Administration (FDA) to treat angina, a heart condition.
The team is led by College of Science professor and biological chemist Wenshe Ray Liu, a 2018 Texas A&M Presidential Impact Fellow and holder of the Gradipore Chair in the Texas A&M Department of Chemistry, and Chien-Te Kent Tseng, professor and director of the SARS/MERS/COVID-19 Laboratory at UTMB. Liu also holds joint faculty appointments in Texas A&M’s Colleges of Medicine and Agriculture and Life Sciences.
“Only one FDA-approved medication is currently available, remdesivir, to provide limited benefits to COVID-19 patients, and the virus may easily evade it,” Liu said. “Finding alternative medicines is imperative. Our team screened more than 30 FDA/European Medicines Agency approved drugs for their ability to inhibit SARS-CoV-2’s entry into human cells. The study found bepridil to offer the most potential for treatment of COVID-19. As a result, we are advocating for the serious consideration of using bepridil in clinical tests related to SARS-CoV-2.”
The Texas A&M-UTMB study, published by the peer-reviewed journal Proceedings of the National Academy of Sciences of the United States of America (PNAS), is now available online and scheduled for print publication on March 9.
The team, which includes six other researchers from Texas A&M and four from UTMB, now plans to advance their work to animal models with a potential for clinical trials.
In addition to Liu, the team includes Shiqing Xu, research associate professor; Kai S. Yang, postdoctoral research associate; and graduate students Erol C. Vatansever, Kaci C. Kratch and Chia-Chuan Cho, all from the Department of Chemistry, College of Science; and Drake M. Mellott, graduate student, Department of Biochemistry and Biophysics, College of Agriculture and Life Sciences, all from Texas A&M; and UTMB colleagues Aleksandra K. Drelich, Kempaiah Rayavara Kempaiah, Jason C. Hsu and Chien-Te K. Tseng.
The project received seed funding in 2020 from the Texas A&M X-Grants program, an initiative of the 10-year, $100 million President’s Excellence Fund, as well as the Texas A&M Translational Investment Fund.
Liu, who is a member of the Texas A&M Emergency Management Advisory Group, was the first person to identify remdesivir as the only viable medicine for treating COVID-19 in a January 2020 research study. At the time, he believed so strongly in its singular effectiveness that he refocused his entire research group from cancer to COVID-19, challenging them to find additional drugs capable of combatting the novel coronavirus pandemic then rapidly spreading across the globe.
To learn more about the Liu group and related research, visit https://www.chem.tamu.edu/rgroup/liu/.
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