Texas A&M Scientists Unravel Mystery Behind Key Signaling Pathway in Antiviral Immune Responses

Sep 30, 2020
"Because cGAS binds nucleosomes much more tightly than free DNA, which includes non-nucleosome-bound host DNA, cGAS cannot be activated by free DNA when it is associated with the nucleosome complex. This interaction likely prohibits similar interactions with other crucial nucleosome-binding proteins involved in DNA damage repair, epigenetic regulation, cancer and cell death. The cGAS-STING pathway’s precise role in those processes considering nucleosome-mediated cGAS inactivation needs to be determined through future studies.”
Dr. Wenshe Ray Liu, Texas A&M chemist and Presidential Impact Fellow